Jack Doyle was born May 5, 1990, in Indianapolis, Indiana. He is a tight end in the NFL. Western Kentucky was the only Football Bowl Subdivision program to offer Doyle an athletic scholarship. During Doyle's freshman year in 2009, he started 10 games at tight end. Doyle finished with 365 yards on 37 catches with one touchdown. After the season, Doyle was named to Phil Steele's National All-Freshman squad.
Doyle started seven games as a sophomore. Even though he suffered a season-ending injury, he still caught 20 passes for 224 yards and two touchdowns. During his junior year, Doyle started all 12 games, had 52 receptions for 614 receiving yards, and was named second-team All-Sun Belt.
Doyle, as a senior, had his best season. He started all 13 games and caught a total of 53 passes for 566 yards and five touchdowns. Because of the stellar season, Doyle was named first-team All-Sun Belt. He was also a semifinalist for the Mackey Award. During his time at Western Kentucky, Doyle was a three-time captain.
On January 26, 2013, Doyle played in the 2013 Senior Bowl as part of the Oakland Raiders head coach Dennis Allen's North team that lost 21–16 to Detroit Lions' head coach Jim Schwartz' South team. He did not receive an invitation to participate at the NFL Scouting Combine. On February 21, 2013, Doyle held a private pro day and had scouts and team representatives from 20 NFL teams attend. He ran the majority of the combine and positional drills but elected to skip the bench press. Doyle was mentored by former Indianapolis Colts tight end Ken Dilger in preparation for his pro day. At the conclusion of the pre-draft process, Doyle was projected to be a seventh-round pick or priority undrafted free agent by NFL draft experts and scouts. He was ranked as the 20th best tight end prospect in the draft by DraftScout.com. Doyle went undrafted in the 2013 NFL Draft.
On May 1, 2013, the Tennessee Titans signed Doyle to a three-year, $1.49 million contract as an undrafted free agent. Throughout training camp, Doyle competed to be a backup tight end against Taylor Thompson, Brandon Barden, and Martell Webb. On August 31, 2013, the Tennessee Titans waived Doyle as part of their final roster cuts but planned to sign him to their practice squad after clearing waivers. On September 1, 2013, the Indianapolis Colts claimed Doyle off of waivers and added him to their active roster.
In 2014 During training camp, Doyle competed for a roster spot as a backup tight end. In 2015 Head coach Chuck Pagano named Doyle the third tight end on the depth chart to begin the regular season. In 2016 he was a starter and completed the season with 59 receptions for 584 receiving yards and five touchdowns in 16 games and 14 starts. On January 21, 2018, it was announced that Doyle was selected to play in the 2018 Pro Bowl. On December 6, 2019, Doyle signed a three-year, $21 million contract extension with the Colts through the 2022 season. In 2019, he started all 16 games and finished with 43 receptions for 448 yards and four touchdowns. After the season, Doyle was named to the 2020 Pro Bowl as a replacement for Travis Kelce, who played in Super Bowl LIV.