Nick Madrigal was born March 5, 1997, in Sacramento, California. He is a second baseman in the MLB.
As a freshman at Oregon State, Madrigal started in 49 games and hit .333/.380/.456 with one home run and 29 runs batted in (RBIs). He was named the Pac-12 Freshman of the Year and was a first-team All-Pac-12 selection. In 2017, Madrigal's sophomore year, he batted .380 with four home runs and forty RBIs in sixty games and was named the Pac-12 Player of the Year. He was also named to the College World Series All-Tournament Team. In 2018, as a junior, he slashed .367/.428/.511 with three home runs and 34 RBIs in 42 games.
Madrigal was selected fourth overall by the Chicago White Sox in the 2018 Major League Baseball draft. He signed for $6,411,400, and was assigned to the AZL White Sox before being promoted to the Kannapolis Intimidators in July and the Winston-Salem Dash in August. In 43 games between the three clubs, Madrigal slashed .303/.353/.348 with 16 RBIs and eight stolen bases. He returned to Winston-Salem to begin 2019 and was promoted to the Double-A Birmingham Barons in June after slashing .272/.346/.377 with 52 hits, 20 runs scored, and 17 stolen bases in 49 games with the team. Madrigal was named to the 2019 All-Star Futures Game. After the 2019 MLB Trade Deadline, Nick was promoted to the Triple-A Charlotte Knights.
On July 31, 2020, Madrigal was promoted to the MLB. He started at second base and batted ninth against the Kansas City Royals.
Overall with the 2020 Chicago White Sox, Madrigal batted .340 with 11 RBIs in 29 games.
On April 24, 2021, Madrigal got his first walk-off hit in his major league career in the bottom of the ninth inning against the Texas Rangers off of pitcher John King, leading the White Sox to a 2-1 win. On May 17, 2021, Madrigal hit his first major league home run off of J. A. Happ of the Minnesota Twins. Madrigal hit .305/.349/.425 with 2 home runs and 21 RBI in 54 games.
On July 30, 2021, Madrigal was traded along with Codi Heuer to the Chicago Cubs for Craig Kimbrel.
On January 13, 2023, Madrigal agreed to a one-year, $1.225 million contract with the Cubs, avoiding salary arbitration.